FAQ: Who is the study's Principal Investigator?

FAQ: How is the study's principal investigator? 

Dominic D’Agostino, Ph.D


Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic, and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology. His teaching focuses on topics such as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology.

He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC), assisting with efforts towards optimizing the safety, health, and resilience of the warfighter and astronaut. His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, and cancer.

To investigate the mechanisms of these pathologies, he uses a variety of in vivo and in vitro techniques, including radio-telemetry (EEG, EMG), electrophysiology, fluorescence microscopy, confocal microscopy, atomic force microscopy (AFM), biochemical assays, and in vivo bioluminescence imaging. His laboratory has adapted many of these techniques for use inside environmental chambers, which allows them to manipulate oxygen concentrations (from hypoxia to hyperbaric oxygen).

His current project is to identify cellular mechanisms of seizures from CNS oxygen toxicity and to develop mitigation strategies against it. His efforts have focused specifically on measuring brain EEG, neuronal excitability, reactive oxygen species (ROS) production, and biomarkers of oxidative stress.

The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanisms of the ketogenic diet and ketone metabolite supplementation. The shift in brain metabolism (from glucose to ketones) reduces neuronal hyperexcitability, oxidative stress, and enhances brain energy metabolism. This approach can be used to treat a wide variety of pathologies linked pathophysiologically to metabolic dysregulation, including cancer.

Other areas of interest include researching drugs that target cancer-specific metabolic pathways. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments.

His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations, and foundations. With a wide range of research interests, Dominic D’Agostino holds membership in the Undersea and Hyperbaric Medicine Society, Aerospace Medical Association, Society of Neuroscience, American Physiological Society, and the American Association of Cancer Research. He also serves on numerous editorial boards and as a reviewer for dozens of scholarly publications.

Before joining the faculty at USF, D’Agostino completed a postdoctoral fellowship in neuroscience at Boonshoft School of Medicine at Wright State University. A graduate of Robert Wood Johnson Medical School and Rutgers University, Dominic D’Agostino earned his Ph.D. and B.S. from these respective institutions.

Dr. D'Agostino can found on:

Twitter: @DominicDAgosti2
Instagram: @dominic.dagostino.kt
Youtube: KetoNutrition-Dom or ketonutrition.org

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